Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like propertiesArticle Published on 2023-04-052023-06-24 Journal: European journal of medicinal chemistry [Category] 신종인플루엔자, [키워드] 150-cavity drug resistance Influenza virus neuraminidase inhibitors oseltamivir. [DOI] 10.1016/j.ejmech.2023.115275 PMC 바로가기
Antimicrobial peptides: A promising tool to combat multidrug resistance in SARS CoV2 eraArticle Published on 2022-12-012022-11-15 Journal: Microbiological research [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome against SARS-CoV AMP AMPs antimicrobial antimicrobial agent antimicrobial peptide antimicrobial resistance Antiviral antiviral agent antiviral peptides caused Compound coronavirus coronavirus 2 COVID-19 COVID-19 pandemic drug resistance effective Effectiveness highlight highly pathogenic life-threatening mechanism microbial infections peptide respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome coronavirus. therapeutic drug therapeutic strategy Treatment variety viral infection virus [DOI] 10.1016/j.micres.2022.127206 PMC 바로가기
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum SamplesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] 바이오마커, 변종, 치료제, [키워드] Accuracy applied approaches clinical sample clinician Complete COVID-19 pandemic Culture deaths described detect Diagnosis diagnostic test disease drug drug resistance drug susceptibility drugs effective Establishing evaluate evaluated faster genetic marker Genetic variant genetics genomic variant helping identification identify infecting Infectious disease information initial Initially molecular molecular test Mutation Mycobacterium Mycobacterium tuberculosis negatively affected Next-generation sequencing NGS phenotypic Phylogenetic phylogenetically Phylogeny protocol Rapid reducing reliability reported resistance responsible resulting Sample sequenced Sequencing sputum Sputum sample sputum samples Stage strain targeted sequencing TB patient the WHO Treatment Tuberculosis tuberculosis. was used WGS WHO [DOI] 10.1128/spectrum.01252-22 PMC 바로가기
Tools to Alleviate the Drug Resistance in Mycobacterium tuberculosisArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] 진단, [키워드] acid-fast bacillus Antibiotics Asymptomatic cause caused COVID-19 pandemic death detect diagnosed Diagnosis drug Drug discovery drug resistance drug-resistant estimates exhibiting Factor Frequency highlight Host intrinsically isolate isolates majority MDR molecular mechanism mutations mutations. Mycobacterium Mycobacterium tuberculosis Nucleic acid detection pathogen reduced reduction in resistance Treatment treatment regimen Tuberculosis WHO [DOI] 10.3390/molecules27206985 PMC 바로가기
Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sitesArticle Published on 2022-10-122022-11-15 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] 3CL 3CL pro 3CL Protease approach biological property clinically conserved Coronaviruses COVID-19 deep mutational scanning develop drug resistance functional identify inhibitor inhibitors Mutation Nirmatrelvir protease protease inhibitors protease inhibitors. Protein residue reveal SARS-CoV-2 single mutant subset target therapeutic target Tolerance virus viruses [DOI] 10.1016/j.chom.2022.08.003 PMC 바로가기
As the virus evolves, so too must we: a drug developer’s perspective : We need a new paradigm in searching for next-generation countermeasuresArticle Published on 2022-10-102022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition antibody Antiviral approach cellular immunity COVID19 develop drug drug resistance drugs Effect effective Evolution of SARS-CoV-2 Genetic greater HAD HDTx host-directed antiviral Host-directed therapeutics humoral immune immune evasion in sight infections offer omicron Pandemic countermeasures Perspective plasticity population immunity Quasispecies recombinant reduce risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2. selective severity strain Treatment Vaccine variant variants virus [DOI] 10.1186/s12985-022-01887-y PMC 바로가기
Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strainsArticle Published on 2022-10-032022-11-16 Journal: World journal of microbiology & biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Amikacin analyzed antibiotic Antibiotic-resistance Antibiotics Bacteria Bacterial infection Bacterial infections calculated Cell cholesterol Concentration Coverage cytotoxicity drug resistance drug-resistant evaluated Gene Expression highest hospitalized patients IMPROVE inhibited Klebsiella Klebsiella pneumoniae less MBC MDR mechanism mRNA expression multi-drug resistant Niosome Niosome. occur positive ranged reduced SARS-CoV-2 significantly Spread stability strain Strains Toxicity Treatment were measured [DOI] 10.1007/s11274-022-03405-2 PMC 바로가기
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기
Antiretroviral drug switches to zidovudine-based regimens and loss to follow-up during the first COVID-19 lockdown in Bali, IndonesiaArticle Published on 2022-10-012022-11-15 Journal: HIV medicine [Category] 치료제, [키워드] anonymized data antiretroviral antiretroviral drug antiretroviral treatment ART Care collected Combination COVID-19 COVID-19 pandemic demographic data diagnosed drug resistance effort Follow-up greater had no HIV impacted Indonesia information International Laboratory testing lockdown Lockdown. majority men National numbers of patient Patient Record regimen regimens Registered required retrospective Sex Support switching Toxicity Treatment Viral load virological suppression with HIV [DOI] 10.1111/hiv.13298 PMC 바로가기